HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1612545Generated: October 26, 2026
1-Deoxy-1-(methylamino)hexitol → 1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-{4-[methyl-(2,3,4,5,6-pentahydroxyhexyl)amino]butoxy}phenyl)azetidin-2-one
https://huagongshe.com/reaction/1612545
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Deoxy-1-(methylamino)hexitol | HCID 4049 | — |
| Reactant | 1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-hydroxypropyl]-4-[4-(4-iodobutoxy)phenyl]azetidin-2-one | HCID 22252048 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-{4-[methyl-(2,3,4,5,6-pentahydroxyhexyl)amino]butoxy}phenyl)azetidin-2-one | HCID 22252044 | 79.9% |
Reaction Steps
100 mg of 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(4-iodobutoxy)phenyl]azetidin-2-one are dissolved in 5 ml of absolute dimethylformamide. 132 mg of 6-methylaminohexane-1,2,3,4,5-pentaol are then added, and the reaction solution is stirred at 50° C. for 2 h. After concentration using a rotary evaporator and oil pump vacuum at 40° C., the residue is purified by preparative HPLC. The product (89 mg) is obtained as an oil. C35H44F2N2O8 (658) MS (ESI): M+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06992067B2 |
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| Source dataset | uspto-grants-2006_01 |
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| ORD ID | ord-5ec6c99a704b40fda53f633d31b97671 |
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| Source note | uspto-grants-2006_01 |
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