Diethyl Ether → HCID 19775943, compound

Participants

Reaction Steps

The dinitrobenzene obtained in Step A (10.0 g, 24.3 mmol) was dissolved in N,N-dimethylformamide (60 cm 3). Triethylamine (5.1 cm3, 36.5 mmol) and DL 2-aminopropanol 2.9 cm3, 36.5 mmol) were added, and the mixture was stirred at room temperature for 21 hours, and then heated at 70° C. for a further 3 hours. The mixture was cooled to room temperature, poured into diethyl ether (500 cm3) and washed with water (3×300 cm3). The organic layer was dried (MgSO4), filtered and evaporated under reduced pressure to give DL 2-[5-(4-bromo-1-methyl-5-trifluoromethyl-1H-pyrazol -3-yloxy)-2-nitrophenylamino]propan-1-ol (10.15 g) as an orange solid m.p 116°-118° C.

Provenance & Evidence