Formaldehyde → HCID 178440757, compound

Participants

Reaction Conditions

Reaction Steps

4-Mercaptopyridine (11.1 g, 0.1 mol), 2,6-di-tertbutylphenol (20,6 g, 0.1 mol), paraformaldehyde (3.0 g, 0.1M) and di-n-butylamine (1 ml) are heated at 80° C. for two and half hours, after which time, thin layer chromatography (t.l.c.) showed the reaction to be complete. The reaction mixture is cooled to 50° C., ethanol (100 ml) is added and the product is crystallised as a pale yellow solid (24.7 g, 78.4% of theory) of m.p. 169°-171° C. (Found C=73.30; H=8.49; N=4.31; S=9.71 C20H27NOS requires C=72.95; H=8.21; N=4.26 and S=9.73%).

Provenance & Evidence