Formaldehyde → HCID 178441105, compound

Participants

Reaction Steps

5-Mercapto-3-phenyl-1,3,4-thiadiazole-2(3H) thione potassium salt (26.4 g, 0.1 mol), 2,6-di-tertbutylphenol (20.6 g, 0.1 mol), formalin (11 ml) and concentrated sulphuric acid (10 ml) in ethanol (100 ml) are heated, under reflux, for six hours. After this time, the ethanol is removed by rotary evaporation, and partitioned between ethyl acetate and water. The organic phase is dried over magnesium sulphate, filtered and the solvent removed in vacuo. A yellow oil is left (29.5 g, 66% of theory).

Provenance & Evidence