Hydrazine hydrate (1:1) → HCID 178443470, compound

Participants

Reaction Conditions

Reaction Steps

Step ii) In a 50 ml-three-necked flask, 1.90 g (5.70 mM) of 2-nitro-4-(trans-4-octylcyclohexyl)phenol, 0.35 g of activated carbon, 0.04 g of FeCl3.6H2O and 15 ml of ethanol were placed and heated to 55°-65° C. under stirring. To the mixture, 1.8 ml of 80% hydrazine hydrate was gradually added dropwise and heated to 70° C., followed by stirring for 20 min at 70° C. After the reaction, the reaction mixture was filtered under heating to remove the activated carbon and the filtrate was cooled to room temperature to precipitate a crystal. The crystal was recovered by filtration and recrystallized from ethanol to obtain 1.49 g of 2-amino-4-(trans-4-octylcyclohexyl)phenol (yield: 86.2%).

Provenance & Evidence