Water → HCID 19776091, compound

Participants

Reaction Steps

27.7 g of 2-(3-cyano-4-fluorophenyl)-5-pentyl-1,3-dioxane (obtainable from 3-cyano-4-fluorobenzaldehyde and 2-pentyl-1,3-propanediol) in 380 ml of dioxane are added dropwise, in the course of 2 hours, to a boiling suspension of 4.0 g of lithium aluminium hydride in 300 ml of the same solvent. When the addition is complete, heating is continued for a further hour and decomposition is then effected with water. The solution is filtered off from the precipitated hydroxide and evaporated down under reduced pressure. 2-(3-Aminomethyl-4-fluorophenyl)-5-pentyl-1,3-dioxane is obtained.

Provenance & Evidence