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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1612618Generated: November 2, 2026

6-Aminohexanoic Acid → Dicyclohexylcarbodiimide

https://huagongshe.com/reaction/1612618

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Aminohexanoic AcidHCID 564—
ReactantTrifluoroacetic anhydrideHCID 9845—
ReactantHCID 19776314HCID 19776314—
ProductDicyclohexylcarbodiimideHCID 10868—
ProductN-HydroxysuccinimideHCID 80170—

Reaction Steps

ε-Aminocaproic acid is reacted with trifluoroacetic anhydride or trifluoroacetyl-N-hydroxysuccinimide and then dicyclohexylcarbodiimide and N-hydroxysuccinimide, giving ε-(trifluoracetamido) caproic acid N-hydroxysuccinimide ester (TFA-CA-NHS).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05190864
Source datasetuspto-grants-1993_03
ORD IDord-77c18fe2dcf24ed1a5a159e79d16b688
Source noteuspto-grants-1993_03