Methanol → HCID 43449021, compound

HRID 1612633Notes

Reaction equation

HRID 1612633 reaction equation
S(=O)(=O)(O)O.[Br:6][C:7]1[CH:8]=[C:9]([N+:17]([O-:19])=[O:18])[C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12]([OH:14])=[O:13].[CH3:20]O>>[CH3:20][O:13][C:12](=[O:14])[C:11]1[CH:15]=[C:7]([Br:6])[CH:8]=[C:9]([N+:17]([O-:19])=[O:18])[C:10]=1[Cl:16]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 22403367HCID 22403367, compound

Product 1

HCID 43449021HCID 43449021, compound

Procedure

20 ml of concentrated sulfuric acid are added dropwise to 51.0 g (0.182 mol) of 5-bromo-2-chloro-3-nitrobenzoic acid and 500 ml of methanol. The mixture is then boiled under reflux for 16 hours and subsequently cooled with an ice bath and the resulting precipitate is isolated by filtration. The mother liquor is concentrated, water is added and the resulting precipitate is isolated by filtration.

Workup

  1. temperatureunder reflux for 16 hours
  2. temperaturesubsequently cooled with an ice bath
  3. customthe resulting precipitate is isolated by filtration
  4. concentrationThe mother liquor is concentrated
  5. additionwater is added
  6. customthe resulting precipitate is isolated by filtration

Sources & evidence

ORD record
ord-a5303357d8d84d18ba2af480fff1586d
Source dataset
uspto-grants-1993_03
Patent number
US05190928

Reaction notes

Loading…