Ammonia → HCID 19090926, compound

HRID 1612692Notes

Reaction equation

HRID 1612692 reaction equation
[C:1]([CH2:3][CH2:4][P:5]([CH:10]([O:15][CH2:16][CH2:17][CH3:18])[O:11][CH2:12][CH2:13][CH3:14])(=[O:9])[O:6][CH2:7][CH3:8])#[N:2].N>C(O)C.[Ni]>[NH2:2][CH2:1][CH2:3][CH2:4][P:5]([CH:10]([O:15][CH2:16][CH2:17][CH3:18])[O:11][CH2:12][CH2:13][CH3:14])(=[O:9])[O:6][CH2:7][CH3:8]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 19090879HCID 19090879, compound

Product 1

HCID 19090926HCID 19090926, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4,35 g of ethyl 2-cyanoethyl(di-n-propyloxymethyl)phosphinate, 10 g of ammonia and 2.3 g of Raney-Nickel in 170 ml of ethanol is hydrogenated for 10.5 hours. The catalyst is filtered off and the solvent is removed by evaporation. The crude oil is purified by distillation to yield ethyl 3-aminopropyl(di-n-propyloxymethyl)phosphinate as a colourless oil.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent is removed by evaporation
  3. distillationThe crude oil is purified by distillation

Sources & evidence

ORD record
ord-d45c80d216b346b68d415e6c1d794fa6
Source dataset
uspto-grants-1993_03
Patent number
US05190933

Reaction notes

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