Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 54431561 | HCID 54431561 | — |
| Catalyst | Rhodium | HCID 23948 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 19776477 | HCID 19776477 | — |
Reaction Steps
A solution of 5.0 g of 2-cyano-1-fluoro-ethenyl(n-butyl)phosphinic acid and 10 ml of liquid ammonia in 150 ml of absolute ethanol is treated with 0.75 g of 5% rhodium on charcoal. The suspension is shaken under hydrogen (20 bars) at 20° C. until thin-layer chromatography indicates complete reaction. The catalyst is removed by filtration and the filtrate is evaporated in vacuo to give a solid. Crystallisation from ethanol/acetone affords 3-amino-1-fluoro-propyl(n-butyl)phosphinic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05190934 |
|---|
| Source dataset | uspto-grants-1993_03 |
|---|
| ORD ID | ord-7f99c09535c34e43b001eaeac1292b23 |
|---|
| Source note | uspto-grants-1993_03 |
|---|
