Formaldehyde → 3-MORPHOLINOMETHYL-3H-OXAZOLO[4,5-b]PYRIDIN-2-ONE

HRID 1612792Notes

Reaction equation

HRID 1612792 reaction equation
[O:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[NH:3][C:2]1=[O:10].[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.[CH2:17]=O>>[O:14]1[CH2:15][CH2:16][N:11]([CH2:17][N:3]2[C:4]3=[N:5][CH:6]=[CH:7][CH:8]=[C:9]3[O:1][C:2]2=[O:10])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 8083MorpholineHCID 2799900Oxazolo(4,5-b)pyridin-2(3H)-one

Product 1

HCID 157454273-MORPHOLINOMETHYL-3H-OXAZOLO[4,5-b]PYRIDIN-2-ONE

Conditions

Temperature
50 °C

Procedure

4.1 g (0.03 mol) of 3H-oxazolo[4,5-b]pyridin-2-one are dissolved in 100 ml of alcohol at 95° C. 2.88 g (0.33 mol) of morpholine and then 3 ml of 30% aqueous formaldehyde solution are added. The mixture is stirred on a water bath at a temperature in the region of 50° C. for one hour 30 minutes, stirring being maintained The mixture is left to stand for one hour at room temperature. The crystals are drained and recrystallized.

Workup

  1. stirringstirring
  2. temperaturebeing maintained The mixture
  3. waitis left
  4. waitto stand for one hour at room temperature
  5. customrecrystallized

Sources & evidence

ORD record
ord-db79fb82612d427ebdf4a76dc822038c
Source dataset
uspto-grants-1993_03
Patent number
US05190960

Reaction notes

Loading…