Benzonitrile, 2-(3,4-dichlorophenoxy)- → HCID 19926666, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 10 g of anhydrous aluminum chloride in 150 ml of dry diethyl ether was added dropwise under nitrogen to a suspension of 3.1 g of lithium aluminum hydride in 150 ml of dry diethyl ether, and the mixture was cooled at 0° C. After 30 min at 0° C., a solution of 5.0 g of 2-(3,4-dichlorophenoxy)benzonitrile in 150 ml of dry diethyl ether was added slowly. The mixture was stirred for 24 h at 25° C., and a concentrated aqueous solution of sodium hydrogen carbonate was added. The precipitate was filtered off, the filtrate was evaporated to dryness, dissolved in ethyl acetate, and acidified with a concentrated solution of hydrochloric acid in ethanol. The precipitate was collected and recrystallized from a mixture of ethanol and diethyl ether, to give in 75% yield 2-(3,4-dichlorophenoxy)benzenemethanamine hydrochloride. mp 213° C.

Provenance & Evidence