Bromodiphenylmethane → 4-Diphenylmethoxy-1-[3-(4-methyl-2-nitrophenoxy)propyl]piperidine

HRID 1612825Notes

Reaction equation

HRID 1612825 reaction equation
[C:1]1([CH:7](Br)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][O:25][C:26]2[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][C:27]=2[N+:33]([O-:35])=[O:34])[CH2:18][CH2:17]1.OC1CCN(CCCOC2C=CC=CC=2[N+]([O-])=O)CC1>>[C:1]1([CH:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:15][CH:16]2[CH2:17][CH2:18][N:19]([CH2:22][CH2:23][CH2:24][O:25][C:26]3[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][C:27]=3[N+:33]([O-:35])=[O:34])[CH2:20][CH2:21]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 236603BromodiphenylmethaneHCID 197766934-Hydroxy-1-[3-(4-methyl-2-nitrophenoxy)propyl]piperidineHCID 197767934-Hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine

Product 1

HCID 197766954-Diphenylmethoxy-1-[3-(4-methyl-2-nitrophenoxy)propyl]piperidine

Procedure

The procedure of Example 1 (a) was repeated except for using diphenylmethyl bromide and 4-hydroxy-1-[3-(4-methyl-2-nitrophenoxy)propyl]piperidine instead of diphenylmethyl bromide and 4-hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine to give oily 4-diphenylmethoxy-1-[3-(4-methyl-2-nitrophenoxy)propyl]piperidine.

Sources & evidence

ORD record
ord-dcf5874bc7034019893f518f6d7d8a71
Source dataset
uspto-grants-1993_03
Patent number
US05190959

Reaction notes

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