Bromodiphenylmethane → 4-Diphenylmethoxy1-[3-methyl-3-(2-nitrophenoxy)propyl]piperidine

HRID 1612829Notes

Reaction equation

HRID 1612829 reaction equation
[C:1]1([CH:7](Br)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH:24]([CH3:35])[O:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[N+:32]([O-:34])=[O:33])[CH2:18][CH2:17]1.OC1CCN(CCCOC2C=CC=CC=2[N+]([O-])=O)CC1>>[C:1]1([CH:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:15][CH:16]2[CH2:17][CH2:18][N:19]([CH2:22][CH2:23][CH:24]([CH3:35])[O:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[N+:32]([O-:34])=[O:33])[CH2:20][CH2:21]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 236603BromodiphenylmethaneHCID 197767154-Hydroxy-1-[3-methyl-3-(2-nitrophenoxy)propyl]piperidineHCID 197767934-Hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine

Product 1

HCID 197767854-Diphenylmethoxy1-[3-methyl-3-(2-nitrophenoxy)propyl]piperidine

Procedure

The procedure of Example 1 (a) was repeated except for using diphenylmethyl bromide and 4-hydroxy-1-[3-methyl-3-(2-nitrophenoxy)propyl]piperidine instead of diphenylmethyl bromide and 4-hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine to give oily 4-diphenylmethoxy1-[3-methyl-3-(2-nitrophenoxy)propyl]piperidine.

Sources & evidence

ORD record
ord-ab635ec9eb2641ea9e1a16ad5c91cb5d
Source dataset
uspto-grants-1993_03
Patent number
US05190959

Reaction notes

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