(4-Chlorophenyl)(pyridin-2-yl)methanol → 4-[(4-Chlorophenyl)-2-pyridylmethoxy]-1-[3-(2-nitrophenoxy)propyl]piperidine

HRID 1612842Notes

Reaction equation

HRID 1612842 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[OH:9])=[CH:4][CH:3]=1.O[CH:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[N+:33]([O-:35])=[O:34])[CH2:19][CH2:18]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[O:9][CH:17]2[CH2:18][CH2:19][N:20]([CH2:23][CH2:24][CH2:25][O:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[N+:33]([O-:35])=[O:34])[CH2:21][CH2:22]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 97719(4-Chlorophenyl)(pyridin-2-yl)methanolHCID 197767934-Hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine2×

Product 1

HCID 197767344-[(4-Chlorophenyl)-2-pyridylmethoxy]-1-[3-(2-nitrophenoxy)propyl]piperidine

Procedure

The procedure of Example 32 (a) was repeated except for using (4-chlorophenyl)-2-pyridylmethanol and 4-hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine instead of phenyl-2-pyridylmethanol and 4-hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine to give oily 4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-[3-(2-nitrophenoxy)propyl]piperidine.

Sources & evidence

ORD record
ord-e03fa41095934e95b9d151b2edf5870d
Source dataset
uspto-grants-1993_03
Patent number
US05190959

Reaction notes

Loading…