4-Hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine → HCID 19776759, compound

HRID 1612850Notes

Reaction equation

HRID 1612850 reaction equation
[C:1]1([CH:7]([Cl:13])[C:8]2[CH:12]=[CH:11][S:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:14][CH:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][CH2:23][O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[N+:31]([O-:33])=[O:32])[CH2:17][CH2:16]1>>[ClH:13].[C:1]1([CH:7]([C:8]2[CH:12]=[CH:11][S:10][CH:9]=2)[O:14][CH:15]2[CH2:16][CH2:17][N:18]([CH2:21][CH2:22][CH2:23][O:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[N+:31]([O-:33])=[O:32])[CH2:19][CH2:20]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 197767934-Hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine2×HCID 19776824HCID 19776824, compound

Product 1

HCID 19776759HCID 19776759, compound

Procedure

The procedure of Example 36 (a) was repeated except for using phenyl-3-thienylmethyl chloride and 4-hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine instead of phenyl-2-thienylmethyl chloride and 4-hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine to give 4-(phenyl-3-thienylmethoxy)-1-[3-(2-nitrophenoxy)propyl]piperidine hydrochloride.

Sources & evidence

ORD record
ord-1c8c35582c7e4817841a19128aeb5810
Source dataset
uspto-grants-1993_03
Patent number
US05190959

Reaction notes

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