p-Toluenesulfonic acid → HCID 54000541, compound

Participants

Reaction Steps

38.2 g (0.158 mol) of the compound from Example 7, dissolved in 500 ml of abs. methylene chloride, are treated with 19.8 g (0.24 mol) of dihydropyran and a spatula tipful of p-toluenesulphonic acid and the mixture is stirred at 25° C. for 14 h. It is washed with aqueous sodium hydrogen carbonate solution and water, dried over sodium sulphate and concentrated in vacuo, and the residue is chromatographed on a silica gel column using petroleum ether.

Provenance & Evidence