Potassium Hydroxide → HCID 19776911, compound

HRID 1612867Notes

Reaction equation

HRID 1612867 reaction equation
C(OC([S:6][C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][C:8]=1[CH2:14][O:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][O:17]1)=S)C.[OH-].[K+]>C(O)C>[CH3:13][C:10]1[CH:11]=[CH:12][C:7]([SH:6])=[C:8]([CH2:14][O:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][O:17]2)[CH:9]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 54000541HCID 54000541, compound

Product 1

HCID 19776911HCID 19776911, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

13.7 g (42 mmol) of the compound from Example 8 are heated overnight under reflux with 9.5 g (0.17 mol) of potassium hydroxide in 70 ml of ethanol. The mixture is concentrated in vacuo, the residue is dissolved in water, the solution is washed with ether, and the aqueous phase is acidified with acetic acid and washed with ether. This ether phase is washed with water, dried over sodium sulphate and concentrated in vacuo.

Workup

  1. concentrationThe mixture is concentrated in vacuo
  2. dissolutionthe residue is dissolved in water
  3. washthe solution is washed with ether
  4. washwashed with ether
  5. washThis ether phase is washed with water
  6. dry with materialdried over sodium sulphate
  7. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-542d3a6448ec4bae9c50de4ab92d3f49
Source dataset
uspto-grants-1993_03
Patent number
US05190971

Reaction notes

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