p-Toluenesulfonic acid → HCID 19776909, compound

Participants

Reaction Steps

302 mg (0.8 mol) of the compound from Example 17 are dissolved in 4.6 ml of methanol and stirred at 25° C. with 36 mg of p-toluenesulphonic acid for 1 h. After addition of 0.45 g of potassium hydroxide, the mixture is heated under reflux overnight. It is concentrated in vacuo, and the residue is adjusted to pH=3 using dilute hydrochloric and washed with ethyl acetate. The organic phase is dried using sodium sulphate and concentrated in vacuo.

Provenance & Evidence