4-Chlorobenzenesulfonyl chloride → Methyl [2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetate

HRID 1612890Notes

Reaction equation

HRID 1612890 reaction equation
C([C@](C(O)=O)(O)[C@](C(=O)C1C=CC=CC=1)(O)C(O)=O)(=O)C1C=CC=CC=1.[NH2:27][CH:28]1[CH2:36][C:35]2[C:30](=[CH:31][CH:32]=[C:33]([CH2:37][C:38]([O:40][CH3:41])=[O:39])[CH:34]=2)[CH2:29]1.[Cl:42][C:43]1[CH:48]=[CH:47][C:46]([S:49](Cl)(=[O:51])=[O:50])=[CH:45][CH:44]=1>>[Cl:42][C:43]1[CH:48]=[CH:47][C:46]([S:49]([NH:27][CH:28]2[CH2:36][C:35]3[C:30](=[CH:31][CH:32]=[C:33]([CH2:37][C:38]([O:40][CH3:41])=[O:39])[CH:34]=3)[CH2:29]2)(=[O:51])=[O:50])=[CH:45][CH:44]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 131716945methyl (+)-(2-aminoindan-5-yl)acetate (+)-dibenzoyl-D-tartaric acid salt

Product 1

HCID 53769737Methyl [2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetate

Procedure

In the same manner as described in Examples 50-(1), methyl (+)-(2-aminoindan-5-yl)acetate (+)-dibenzoyl-D-tartaric acid salt and 4-chlorophenylsulfonyl chloride are treated to give methyl (+)-[2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetate.

Sources & evidence

ORD record
ord-b26a0953b9d34a8ca27be637a9272e91
Source dataset
uspto-grants-1993_03
Patent number
US05190975

Reaction notes

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