Hydrochloric Acid → HCID 19776888, compound

Participants

Reaction Steps

A solution of methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate (Preparation 1) (200 mg), 2-bromomethynaphthalene (138 mg), K2CO3 (89 mg), and Cs2CO3 (34 mg) in 5 mL DMF was stirred at room temperature under nitrogen for 24 hours. The mixture was poured onto 1N HCl, extracted 2× EtOAc, washed 2× brine, dried (MgSO4), and evaporated. Purification of the residue by chromatography (silica gel; hexane/EtOAc 4:1) gave the title compound, used as such for the next step.

Provenance & Evidence