Hydrochloric Acid → HCID 9892605, compound

Participants

Reaction Steps

A solution of the ester from Step 1 (278 mg), 3 mL THF, 3 mL MeOH, and 2.7 mL 1N LiOH was stirred at 80° C. for 4 hours under nitrogen. The solution was cooled, poured onto 1N HCl, extracted 2× EtOAc, washed 2× brine, dried (MgSO4), and evaporated. Purification of the residue by chromatography (silica gel; hexane/EtOAc 2:1) gave the title compound as a solid, m.p. 151.5°-152.5° C.

Provenance & Evidence