HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroformate → 2-Chloro-4-fluoro-methoxycarbonyloxybenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Chloro-4-fluorophenol | HCID 74814 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Chloro-4-fluoro-methoxycarbonyloxybenzene | HCID 10488438 | 115.8% |
Reaction Steps
2-Chloro-4-fluorophenol (83.4 g) was added to a solution of sodium hydroxide (27.7 g) in water (450 ml), and methyl chloroformate (69.2 g) was dropwise added thereto at a temperature of below 10° C. Precipitated crystals were collected by filtration and washed with water to give methyl (2-chloro-4-fluorophenyl) carbonate (134.8 g). M.P., 69°-71° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05191105 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-2e5f3da1c52c418bbbd53526a7a929c4 |
| Source note | uspto-grants-1993_03 |