反应详情

温度

100 °C

To the compound [VIII-1] (28.3 g, 0.12 mole) obtained above are added water (1200 g) and acetic acid (1.5 g), and the pH value thereof is adjusted to pH 4.4 with 5 % aqueous sodium hydroxide solution. The mixture is heated, with stirring at 100° C. for 25 hours. After completion of the reaction, the reaction solution is cooled and extracted twice with methyl isobutyl ketone (300 ml). The extract is separated and concentrated to give a mixture (21.5 g, yield; 76 %) of 4-hydroxy-2-(6-methoxycarbonyl-3-hexynyl)-2-cyclopentenone (racemic 4-hydroxycyclopentenone) and 3-hydroxy-2-(6-methoxycarbonyl-3-hexynyl)-2-cyclopentenone [IX-1] (ratio thereof=6:4).

1. customTo the compound [VIII-1] (28.3 g, 0.12 mole) obtained
2. temperatureThe mixture is heated
3. customAfter completion of the reaction
4. temperaturethe reaction solution is cooled
5. extractionextracted twice with methyl isobutyl ketone (300 ml)
6. customThe extract is separated
7. concentrationconcentrated