Hydrochloric Acid → HCID 19777516, compound

Participants

Reaction Steps

3,5-dinitrobenzamide (18) (412.0 g, 2.00 moles, Aldrich) was added to a suspension of 10% Pd/C (10.4 g) in concentrated HCl (360 ml) and water (3.64 L). The mixture was hydrogenated at 60psi in a Parr hydrogenation apparatus until hydrogen was no longer being consumed. The solution was filtered through a Celite pack and washed with 500 ml water. The filtrate and washings of 3,5-diaminobenzamide bis-hydrochloride (19), were combined and used for the subsequent iodination.

Provenance & Evidence