HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → HCID 19776631, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 7-Chloro-8-cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 15347191 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 19776631 | HCID 19776631 | — |
Reaction Steps
3.05 g of the product from Example 1 and 2.5 ml of pyrrolidine are boiled in 50 ml of dioxane for 3 hours. The mixture is concentrated in vacuo and the residue is taken up in water. The mixture is rendered neutral with 1N HCl. The solid which has precipitated out is filtered off with suction, dried and stirred with acetonitrile. 1.8 of the title compound with a melting point of 274°-6° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05190955 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-65f3214a00c24df4accdc82bb9edb54e |
| Source note | uspto-grants-1993_03 |