Potassium Carbonate → HCID 14986349, compound

Participants

Reaction Steps

A mixture of 5.6 g of 1-(6-iodohexyl)-2,3-bis(phenylmethoxy)benzene, 2.1 g of 3-chloro-4-hydroxybenzoic acid methyl ester and 5.0 g of potassium carbonate in 50 mL of acetone was stirred at reflux for 20 hours. Workup as in Example 16, chromatography on 100 g of silica gel using 15% ethyl acetate-hexane and crystallization from ethyl acetate-hexane gave 3.7 g (59% yield), mp 68°-69°, 3-chloro-4-[6-[2,3-bis (phenylmethoxy)phenyl]hexyloxy]benzoic acid methyl ester.

Provenance & Evidence