Boron tribromide → HCID 14986378, compound

Participants

Reaction Steps

To 5.02 g of 1-[2-hydroxy-4-[4-(2,3-dimethoxyphenyl)butoxy]-3-propylphenyl]ethanone in 300 mL of methylene chloride stirred and cooled at -70° was added 39 mL of 1M boron tribromide in methylene chloride. The reaction mixture was stirred at -70° for 30 minutes and kept at -20° for 5.5 hours. Workup as in Example 32 and recrystallization from acetone-hexane gave 3.81 g (82% yield), mp 103°-105° of 1-[2-hydroxy-4-[4-(2,3-dihydroxyphenyl)butoxy]-3-propylphenyl]ethanone.

Provenance & Evidence