HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 4-[6-[2,3-Bis(phenylmethoxy)phenyl]hexyloxy]benzoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Ethylparaben | HCID 8434 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(6-Bromohexyl)-2,3-bis(phenylmethoxy)benzene | HCID 14986434 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-[6-[2,3-Bis(phenylmethoxy)phenyl]hexyloxy]benzoic acid ethyl ester | HCID 14986445 | 81% |
Reaction Steps
A mixture of 2.4 g (5.3 mmole) of 1-(6-bromohexyl)-2,3-bis-(phenylmethoxy)benzene, 0.88 g (5.3 mmole) of 4-hydroxybenzoic acid ethyl ester, 2.5 g (18 mmole) of potassium carbonate and 0.8 g (5.3 mmole) of sodium iodide in 40 mL of acetone was stirred at reflux for 22 hours. Workup as in Example 16 and recrystallization of the crude product from ethyl acetate-hexane gave 2.3 g, mp 63°-65° (81% yield) of 4-[6-[2,3-bis(phenylmethoxy)phenyl]hexyloxy]benzoic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05191108 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-d6f362eee44e484f87993572966692fc |
| Source note | uspto-grants-1993_03 |