Hydrochloric Acid → Trimethylolpropane

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Reaction Steps

7.8 g (17 mmol) of the crude sulfonate 6 prepared in step 2 are introduced into 60 ml of methanol, and 3 N hydrochloric acid is added dropwise until the pH is less than 5. 400 mg of p-toluenesulfonic acid are subsequently added, the mixture is stirred at room temperature for 21 hours, and methanolic potassium hydroxide solution is added until the mixture is slightly alkaline (pH≈8 to 9). The solvent is removed by distillation in vacuo, and the residue which remains is separated by column chromatography on silica gel using dichloromethane as the eluent, giving 4.1 g of a colorless oil 7.

Provenance & Evidence