HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 18650307, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | L-Pyroglutamic Acid | HCID 7405 | — |
| Reactant | 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline | HCID 27833 | — |
| Reactant | 6,7-Dimethoxy-1,2,3,4-tetrahydronaphthalen-2-amine | HCID 9816265 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 18650307 | HCID 18650307 | 81.6% |
Reaction Steps
To L-pyroglutamic acid (1 g, 7.7 mmoles) in CH3CN (80 mL), 1,2,3,4-tetrahydro-6,7-dimethoxy-2-naphtylamine (1.59 g, 7.7 mmoles) and EEDQ (2.85 g, 11 mmoles) were added under stirring. To the resulting mixture water was added till complete solubilization and the solution was kept at room temperature under stirring for 20 hours. The solvent was evapored and the residue taken up with CHCl3. Et2O was added under stirring. The solid which formed was filtered off giving 2 g of the title compound. Yield 81%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05192759 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-b2ae8d7cfc954e9094b0d93259be5e91 |
| Source note | uspto-grants-1993_03 |