HCID 453660, compound → HCID 18650248, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the 4'-α and 4'-β isomers of 3'-deoxy-4'-hydroxyiminomethylthymidine (40 mg, 0.15 mM) (Formula 24) in 0.5 ml acetic anhydride, was added NaOAc (6 mg, 0.07 mM) and stir at 100° C. for 24 hours. The solvent was removed by evaporation and the residue chromatographed on silica gel using 4% CH3OH/CH2Cl2, affording the 4'-α and 4'-β isomers of 3'-deoxy-4'-cyano-5'-O-acetylthymidine (32 mg, 0.11 mM).

Provenance & Evidence