HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 4'-Cyanothymidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | HCID 18650256 | HCID 18650256 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4'-Cyanothymidine | HCID 452277 | 40.8% |
Reaction Steps
A solution of 4'-cyano-5'-O-acetylthymidine (0.85 g, 2.76 mM) and NH4OH (15 ml) in CH3OH (15 ml) was stirred at 24° C. for 2 hours. The solvent was removed by evaporation under pump vacuum. The residue was purified by flash chromatography on silica gel eluting with (7% CH3OH/CH2Cl2) and by preparative chromatography TLC affording 4'-cyanothymidine (300 mg, 1.12 mM). mp 238.5° C. to 242.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05192749 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-82fc5a100fed4039b7430421385ad4e1 |
| Source note | uspto-grants-1993_03 |