Trifluoroacetic acid → HCID 19775301, compound

Participants

Reaction Steps

Trifluoroacetic acid (25 ml) was added to a solution of benzhydrol (9.2 g) and 2-amino-2-methylpropanol (4.5 g) in methylene chloride (5 ml) and the mixture was stirred at room temperature for 3 hours and evaporated. The residue was partitioned between water and ethyl acetate and the organic layer was washed with water, dried over magnesium sulphate and evaporated. The residue was triturated with hexane and recrystallised from ethyl acetate to give the title compound as a colourless solid (2.98 g, 16%), m.p. 160°-161°.

Provenance & Evidence