HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → HCID 19775311, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| Reactant | 1-(2-Bromoethyl)-4-methoxybenzene | HCID 84427 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 19775311 | HCID 19775311 | 60% |
Reaction Steps
A mixture of 2-amino-2-methylpropanol (4.46 g), 4-methoxyphenethyl bromide (10.76 g), potassium carbonate (13.8 g) and potassium iodide (8.3 g) in acetonitrile (100 ml) was heated under reflux for 20 hours and evaporated. The residue was partitioned between ethyl acetate and water and the organic layer was dried over sodium sulphate and evaporated. The residual solid was recrystallised from ethyl acetate/hexane to give the title compound (6.6 g, 60%), m.p. 114°-115°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05192765 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-74746d1b21d24fc2863c60133fc01493 |
| Source note | uspto-grants-1993_03 |