Phthalic Anhydride → HCID 19775565, compound

HRID 1613231Notes

Reaction equation

HRID 1613231 reaction equation
[CH3:1][C:2]1[S:3][C:4]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)=[C:5]([CH3:7])[N:6]=1.[C:16]1(=[O:26])[O:21][C:19](=[O:20])[C:18]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:17]12>C(#N)C>[CH3:1][C:2]1[S:3][C:4]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]([C:17]3[CH:25]=[CH:24][CH:23]=[CH:22][C:18]=3[C:19]([OH:21])=[O:20])=[O:26])=[CH:11][CH:10]=2)=[C:5]([CH3:7])[N:6]=1

Participants

4

Reactant 2

HCID 6811Phthalic AnhydrideHCID 19775574HCID 19775574, compound

Product 1

HCID 19775565HCID 19775565, compoundYield 66.7%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3 g of 2,4-dimethyl-5-(4-aminobenzyl)thiazole are dissolved in 75 ml of acetonitrile, and 2 g of phthalic anhydride are added in portions. The medium is stirred for 6 hours at room temperature and the precipitate is then filtered off and washed with ethyl acetate to give 3.3 g of 2-[4-((2,4-dimethylthiazol-5-yl)methyl)phenylaminocarbonyl]benzoic acid in the form of crystals melting at 182° C.

Workup

  1. filtrationthe precipitate is then filtered off
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-41a674eba94b4a57997f3a0b912cc894
Source dataset
uspto-grants-1993_03
Patent number
US05192781

Reaction notes

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