Ethyl 4-bromobutyrate → HCID 24835912, compound

HRID 1613237Notes

Reaction equation

HRID 1613237 reaction equation
[C:1](=[S:4])([S-:3])[NH2:2].[NH4+].Br[CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11]>C(O)C>[NH2:2][C:1]([S:3][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[S:4]

Participants

4

Reactant 2

HCID 76300Ethyl 4-bromobutyrateHCID 11083854Ammonium dithiocarbamate

Product 1

HCID 24835912HCID 24835912, compoundYield 101%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 10 g of ammonium dithiocarbamate (i.e. 34 g of a 30% aqueous solution) and 17.7 g of ethyl 4-bromobutyrate in 70 ml of ethanol is stirred for 2 days at room temperature. The reaction medium is extracted with methylene chloride and the organic phase is dried and then concentrated to give 19 g of ethyl 4-(aminothiocarbonylmercapto)butyrate in the form of a semicrystalline yellow oil.

Workup

  1. extractionThe reaction medium is extracted with methylene chloride
  2. customthe organic phase is dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-a3677821db8c46f2af3ea2cb60e256f1
Source dataset
uspto-grants-1993_03
Patent number
US05192781

Reaction notes

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