Water → HCID 19775579, compound

Participants

Reaction Steps

3 g of ethyl 4-[[4-propyl-5-(4-nitrobenzyl)thiazol-2-yl]mercapto]butyrate in 50 ml of ethanol are hydrogenated at normal pressure and room temperature in the presence of Raney nickel. After filtration of the catalyst and concentration of the filtrate, the brown oil obtained is taken up with acidified water. The aqueous phase is extracted with chloroform, rendered basic with dilute sodium hydroxide and extracted with ether. The ether solution is dried and concentrated to give a yellow oil, which is purified on a silica column (eluent: 7/3 cyclohexane/ethyl acetate) to give 0.6 g of ethyl 4-[[4-propyl-5-(4-aminobenzyl)thiazol-2-yl]mercapto]butyrate in the form of a pink oil.

Provenance & Evidence