2-Amino-5-(4-nitrobenzyl)-4-propylthiazole → 2-Amino-5-(4-aminobenzyl)-4-propylthiazole

HRID 1613245Notes

Reaction equation

HRID 1613245 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)=[C:5]([CH2:7][CH2:8][CH3:9])[N:6]=1>C(O)C>[NH2:1][C:2]1[S:3][C:4]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=2)=[C:5]([CH2:7][CH2:8][CH3:9])[N:6]=1

Participants

3

Reactant 1

HCID 197755452-Amino-5-(4-nitrobenzyl)-4-propylthiazole

Product 1

HCID 197755512-Amino-5-(4-aminobenzyl)-4-propylthiazoleYield 59.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.0 g of 2-amino-5-(4-nitrobenzyl)-4-propylthiazole (13 mmol) in 100 ml of ethanol are hydrogenated according to Example 25. 1.9 g of 2-amino-5-(4-aminobenzyl)-4-propylthiazole are obtained in the form of a brown oil.

Sources & evidence

ORD record
ord-6b66d46eaf974841b2bea81bed592c35
Source dataset
uspto-grants-1993_03
Patent number
US05192781

Reaction notes

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