Thioacetamide → HCID 19775547, compound

Participants

Reaction Steps

An equimolar mixture (19.6 mmol) of 2-chloro-1-(4-nitrophenyl)octan-3-one and thioacetamide is heated at 60° C. for 24 hours. After cooling to room temperature, the reaction mixture is concentrated and taken up in isopropyl ether to give 1.7 g of 2-methyl-5-(4-nitrobenzyl)-4-pentylthiazole, which is a pale yellow solid melting at 57° C.

Provenance & Evidence