反应详情

1.9 g of 2-amino-5-(4-aminobenzyl)-4-propylthiazole (7.65 mmol) and 1.7 g of 3,6-dichlorophthalic anhydride are reacted under the conditions of Example 26. The reaction mixture is stirred for one day at room temperature. After concentration, a beige solid is obtained which is triturated in ether to give 2.2 g of 2-[4-(2-amino-4-propylthiazol-5-ylmethyl)phenylaminocarbonyl]-3,6-dichlorobenzoic acid in the form of a beige powder melting at 153° C.

1. concentrationAfter concentration
2. customa beige solid is obtained which
3. customis triturated in ether