Thiourea → HCID 19775548, compound

Participants

Reaction Steps

An equimolar mixture (18 mmol) of 2-chloro-1-(4-nitrophenyl)octan-3-one and thiourea is heated at 60° C. for 6 hours. The reaction mixture is taken up in methylene chloride and filtered. After concentration, the filtrate is washed with water which has been rendered basic, and extracted with chloroform to give 3 g of 2-amino-5-(4-nitrobenzyl)-4-pentylthiazole in the form of a brown oil, which is used as such for the next step.

Provenance & Evidence