Thionyl Chloride → Benzene, (chloromethyl)phenoxy-

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Reaction Steps

Into a 1 liter round bottom flask equipped with a stirrer, a condenser, a thermometer and an addition funnel are charged 25 g (0.125 mole) of o-phenoxybenzyl alcohol and 250 ml of benzene. Thionyl chloride (18.0 g, 0.15 mole) is added dropwise at room temperature. After the addition, the reaction mixture is heated to reflux for 2 hours. Solvent is then evaporated under vacuum to give 29 g of product.

Provenance & Evidence