Chlorosulfamic acid → HCID 19733464, compound

HRID 1613368Notes

Reaction equation

HRID 1613368 reaction equation
[S:1](Cl)(=[O:4])(=[O:3])[NH2:2].[O:6]([CH2:13][CH:14]([OH:16])[CH3:15])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[O:6]([CH2:13][CH:14]([O:16][S:1](=[O:4])(=[O:3])[NH2:2])[CH3:15])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 24499Chlorosulfamic acidHCID 928391-Phenoxy-2-propanol

Product 1

HCID 19733464HCID 19733464, compound

Procedure

The title compound was prepared by procedures of Example 22 from sulfamoyl chloride and 3-phenoxy-2-propanol through the partitioning and final evaporation to give an oil as residue. The oil was purified by chromatography using a 4.5 cm×100 cm glass column packed with 500 g of silica gel and methylene chloride as eluting agent. Fractions containing the title compound were combined and the solvent was evaporated under reduced pressure to give a 37% yield of an oil which solidified on standing, mp 57°-60° C.

Workup

  1. customevaporation
  2. customto give an oil as residue
  3. customThe oil was purified by chromatography
  4. washas eluting agent
  5. additionFractions containing the title compound
  6. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-17893802b7514ba2b83a65e657e8a42a
Source dataset
uspto-grants-1993_03
Patent number
US05192785

Reaction notes

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