Chlorosulfamic acid → HCID 10060816, compound

HRID 1613440Notes

Reaction equation

HRID 1613440 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=2)[CH:4]=[CH:5][N:6]=1.[S:14](Cl)(=[O:17])(=[O:16])[NH2:15]>C(#N)C>[CH3:1][C:2]1[N:3]([C:7]2[CH:8]=[C:9]([O:13][S:14](=[O:17])(=[O:16])[NH2:15])[CH:10]=[CH:11][CH:12]=2)[CH:4]=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 24499Chlorosulfamic acidHCID 10058013HCID 10058013, compound

Product 1

HCID 10060816HCID 10060816, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

A slurry of 8.7 g (0.05 mole) of 3-(2-methyl-1H-imidazol-1-yl)phenol in 150 ml of acetonitrile was treated with a solution of 0.05 mole of sulfamoyl chloride in 20 ml of acetonitrile. The mixture dissolved and slowly deposited off-white crystals over the period of 24 hr. The precipitate was collected and triturated with hot absolute ethanol. The slurry was cooled and the precipitate was collected and dried to give 4.0 g (32%) of off-white powder, monohydrochloride, mp 197°-200° C.

Workup

  1. dissolutionThe mixture dissolved
  2. customover the period of 24 hr
  3. customThe precipitate was collected
  4. customtriturated with hot absolute ethanol
  5. temperatureThe slurry was cooled
  6. customthe precipitate was collected
  7. customdried

Sources & evidence

ORD record
ord-3a27961ea0ec4a8e91d4204b59b25bb0
Source dataset
uspto-grants-1993_03
Patent number
US05192785

Reaction notes

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