Potassium Iodide → Ethyl 2-[4-(3,5-difluorophenoxy)phenoxy]ethylcarbamate

Participants

Reaction Steps

27.6 g of finely pulverulent potassium carbonate and 1.0 g of pulverized potassium iodide are added to a solution of 22.2 g of 4-(3,5-difluorophenoxy)phenol in 80 ml of dimethylformamide. 18.2 g of ethyl 2-chloroethylcarbamate are furthermore added dropwise, and the reaction mixture is heated for 16 hours at +95° C., with stirring. The reaction mixture is then filtered, the filtrate is poured into 400 ml of water, and the mixture is extracted three times using diethyl ether. The combined organic phases are washed with water and dried over sodium sulfate, and the solvent is distilled off. The residue is purified over silica gel (eluent: n-hexane/diethyl ether, 3:1), which gives pure ethyl 2-[4-(3,5-difluorophenoxy)phenoxy]ethylcarbamate as a colourless solid of melting point 54°-56° C., which solidifies in crystalline form; yield: 92% of theory.

Provenance & Evidence