Diethyl Ether → 1-(4-bromo-phenyl)-3-cyclopropyl-6,8-dimethyl-5-phenylamino-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione

HRID 161347Notes

Reaction equation

HRID 161347 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5](-[n:8]2[c:9](=[O:36])[n:10]([CH:33]3[CH2:34][CH2:35]3)[c:11](=[O:32])[c:12]3[c:13]2[n:14]([CH3:31])[c:15](=[O:30])[c:16]([CH3:29])[c:17]3[O:18][S:19]([c:20]2[cH:21][cH:22][c:23]([CH3:24])[cH:25][cH:26]2)(=[O:27])=[O:28])[cH:6][cH:7]1.[CH2:50]([O:51][CH2:52][CH3:53])[CH3:54].[CH3:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49].[NH2:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1>>[Br:1][c:2]1[cH:3][cH:4][c:5](-[n:8]2[c:9](=[O:36])[n:10]([CH:33]3[CH2:34][CH2:35]3)[c:11](=[O:32])[c:12]3[c:13]2[n:14]([CH3:31])[c:15](=[O:30])[c:16]([CH3:29])[c:17]3[NH:37][c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 6115AnilineHCID 8058HexaneHCID 59717126Toluene-4-sulfonic acid 1-(4-bromo-phenyl)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydro-pyrido[2,3-d]pyrimidin-5-yl ester

Product 1

HCID 597174211-(4-bromo-phenyl)-3-cyclopropyl-6,8-dimethyl-5-phenylamino-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione

Sources & evidence

ORD record
ord-5bdddc1e6a00449aa572b186984d5ee4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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