Benzyl Alcohol → HCID 86744908, compound

Participants

Reaction Steps

cis-3-Aminocyclohexanecarboxylic acid hydrochloride (8.78 g, 49 mmole) was refluxed for 24 hours with benzyl alcohol (26.4 g, 0.24 mole) and para-toluenesulphonic acid monohydrate (11.17 g, 0.59 mole) in toluene (150 ml) using a Dean-Stark trap. On cooling and addition of diethyl ether the required benzyl ester crystallised as a white solid (18.68 g, 94%), m.p. 148°-150° C. Found: C,62.21; H,6.75; N,3.34. C21H27NO5S requires C,62.20; H,6.71; N,3.45%.

Provenance & Evidence