Lithium Hydroxide → HCID 11756030, compound

Participants

Reaction Steps

The compound of Example 4 (25 mg, 47.7 μmol) along with 1.0 ml of 4:1 methanol/THF, and 0.09 ml of 1N lithium hydroxide were stirred at 0° C. for thirty minutes. An additional 0.09 ml of 1N lithium hydroxide was added and the reaction mixture was stirred at room temperature for 45 minutes. The reaction mixture was poured into 0.5N hydrochloric acid/ethyl acetate. The ethyl acetate layer was washed with brine, dried over sodium sulfate, and concentrated under vacuum to give the product; melting point 136-139° C. High resolution mass spectrum m/e 510.2471 (calculated for C29H36NO7 (M+H), 510.2492).

Provenance & Evidence