Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | 3-{7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]-8-propyl-3,4-dihydro-2H-1-benzopyran-2-yl}propanoic acid | HCID 146951 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | HCID 19762688 | HCID 19762688 | — |
Reaction Steps
7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-propionic acid (1 mmol) is dissolved in acetone containing 2.5 equivalents of potassium hydroxide and 3 equivalents of dimethyl sulfate. The mixture is heated at 40° C. for about 10 hours then cooled. The solvent is removed in vacuo, and the residue is partitioned between ethyl acetate and water. The organic layer is separated and dried over magnesium sulfate. Removal of the volatiles in vacuo gives the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05192782 |
|---|
| Source dataset | uspto-grants-1993_03 |
|---|
| ORD ID | ord-a3ab0c2e138b4ff18e6f590c77d6eed2 |
|---|
| Source note | uspto-grants-1993_03 |
|---|
